Ever wonder what the best time is to drink your coffee? You probably know it is not a good idea to drink part of your daily dose of caffeine in the afternoon. Especially for those who have problems sleeping. But, do you ever drink your coffee and feel like it just didn’t work? I know I have that feeling sometimes. The explanation for this has to with a concept that I think is extremely interesting but rarely discussed: chronopharmacology.
Chronopharmacology can be defined as the study of the interaction of biological rhythms and drug action. One of the most important biological rhythms is your circadian clock. This endogenous 24-hour clock alters your physiology and behavior in variety of ways but it can also alter many properties of drugs including drug safety (pharmacovigilance), pharmacokinetics, drug efficacy, and perhaps even drug tolerance.
But, what part of the brain produces this 24-hour cycle and what signals does it receive in order for it to do so properly? It has been known for a long time that light is a strong zeitgeber. A zeitgeber is a term used in chronobiology for describing an environmental stimulus that influences biological rhythms. In the case of mammals, light is by far the most powerful. Following the discovery of connections between the retina and hypothalamus (the retinohypothalamic tract), investigations were aimed at the hypothalamus as the putative master clock. Indeed, in some of the most elegant brain lesion experiments, Inouye and Kawamura (1979) provided some of the first evidence demonstrating that the hypothalamus acts as the master clock in controlling the circadian rhythm. By creating an “island” in the brain by methodically cutting the hypothalamus away from any surrounding tissue, the circadian clock was completely lost (Inouye and Kawamura, 1979).
What does that mean? Well, the output of the hypothalamus nucleus (the suprachiasmatic nucleus or SCN) that controls the circadian clock has a variety of functions. The SCN controls your sleep-wake cycle, feeding and energy consumption, sugar homeostasis, and in addition to a few other things it controls your hormones. And, with respect to your alertness, the SCN’s control of cortisol (often referred to as the “stress” hormone) production is extremely important.
Most readers here enjoy–-and desperately need-–their morning coffee. But if you are drinking your morning coffee at 8 a.m., is that really the best time? The circadian rhythm of cortisol production would suggest not.
Drug tolerance is an important subject, especially in the case of caffeine since most of us overuse this drug. Therefore, if we are drinking caffeine at a time when your cortisol concentration in the blood is at its peak, you probably should not be drinking it. This is because cortisol production is strongly related to your level of alertness and it just so happens that cortisol peaks for your 24-hour rhythm between 8 a.m. and 9 a.m. on average (Debono et al., 2009). Therefore, you are drinking caffeine at a time when you are already approaching your maximal level of alertness naturally.
One of the key principles of pharmacology is use of a drug when it is needed (although I’m sure some scientists might argue that caffeine is always needed). Otherwise, we can develop tolerance to a drug administered at the same dose. In other words, the same cup of morning coffee will become less effective and this is probably why I need a shot of espresso in mine now.
Although your cortisol levels peak between 8 a.m. and 9 a.m., there are a few other times where–on average–blood levels peak again, like between noon and 1 p.m., and between 5:30 p.m. and 6:30 p.m. In the morning then, your coffee will probably be the most effective if you enjoy it between 9:30 a.m. and 11:30 a.m., when your cortisol levels are dropping before the next spike.
A version of this article originally appeared on BrainFacts.org. BrainFacts.org provides information about the field’s understanding of causes, symptoms, and outcomes of brain disorders. The site is a public information initiative of The Kavli Foundation, the Gatsby Charitable Foundation, and the Society for Neuroscience, all leading global nonprofit organizations working to advance brain research. Leading neuroscientists from around the world form the BrainFacts.org editorial board.