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46. Sam Calagione

Dogfish Head Craft Brewery

Sam Calagione, founder of what's now one of America's fastest-growing craft breweries, is living proof that drinking doesn't kill brain cells. Buoyed by Calagione's passion for off-kilter concoctions—such as a stout made with chicory and St. John's wort, "the world's only antidepressant depressant," he jokes—Dogfish revenue hit $44.8 million last year. Next up: selling Noble Rot, a beer Calagione's team made from bacteria-infected grapes.

Process

Learn more about the off-kilter founder of America's fastest-growing craft brewery, Dogfish Head, in these videos.

We don't see any point in doing what's already been done.

Inspiration

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