Horowitz, No. 8 on our 100 Most Creative People in Business list, cofounded Silicon Valley VC firm Andreessen Horowitz, which raised $2.7 billion in its first three years and backed Bump, Facebook, Foursquare, Groupon, Pinterest, Twitter, and Zynga--all without "adult supervision."

The Voto Latino founders mobilze a growing consituency of voters with mobile tech and grassroots savvy. 

Jared Leto has a posse--and he's harnessed its support for several startups aimed at shaking up the music industry. Submit questions here or by tweeting questions to @FastCompany with the hashtag #fcchat.   

"There's a lot of big-time people who have others tweet for them," says Shaquille O'Neal, one of our 2012 Most Creative People, "So I want people to know: This is me; this is how I'm doing it."

In this video and profile, Fuck Cancer founder (and No. 38 Most Creative Person) Cohen talks about her unorthodox approaches to cancer awarness--including celebrity voicemails and visualizing Justin Bieber checking his junk. 

Before she was head of consumer marketing for Facebook (now on the eve of its unprecedented IPO), our No. 2 Most Creative Person pushed Nike to "Just Do It" and Levi's to "Go Forth." Here's her advice for you.

The comedic actress, writer, and front woman of the band Wild Flag finds creative inspiration in people's most uncomfortable moments. "It's usually where someone's belief system kind of goes off the rails."

The actress, mom, and Most Creative Person shares the story of developing a baby-care and household-cleaner company, The Honest Company, with a flagship product that's the largest recurring purchase of new parents.