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For donors who are a match, the procedure can be simple. A relatively new peripheral stem-cell blood transplantation method means the process is only slightly more labor-intensive than giving blood. In the past, donors faced a painful pelvic marrow extraction. “People are starting to finally overcome the stigma that this is a horribly invasive procedure and you only do it when a family member or friend is in need of a transplant,” reports Foley.