Depends on what you are building. Are you building an ecommerce site, an application, a social site, a marketing site, a content site? Having your users in mind is always required, but should you be goal centered, task centered, user centered, activity centered, social object centered? In the end your site should facilitate whatever the user is trying to do. The interaction should be frictionless and valuable.

What your website should not be is a reflection of your organization or the egos of your managers. People don't care and they will go somewhere else. Even if you are the most famous company in the world, you do not have the "right" to succeed. You have to earn it.

My 7 cents (inflation),
mTp