A decade ago, this magazine began chronicling a new era in business. To celebrate our anniversary, we're looking out to the next one. In this slideshow (and Part I) meet the people, technology, ideas, and trends that will shape how we work and live over the 10 years ahead.

Ruckus Wireless has rolled out a technology that pings voice, music, photos, even high-grade video around a home Wi-Fi network. When other appliances--or heating and lighting systems--come Wi-Fi ready, you'll be able to preheat the oven from your cell phone. One U.S. company recently ordered 15,000 Ruckus boxes.

MicroChips, the company Langer cofounded with John Santini, is making the new electronic drug chip a reality. Residing under the skin, the chip consists of thousands of tiny, individually sealed reservoirs containing one or more drugs. These reservoirs can be programmed to open at a specific time or operated by a wireless remote control.

When Fritz sold his logistics firm to UPS in 2001 he decided to apply his expertise in getting things from here to there to humanitarian aid. The Fritz Institute has designed, built, and deployed free logistics software; convened the first association for aid workers; and launched a consortium of companies that lend logistics experts.

The Spanish-born Urquiola was the buzz of the Milan Furniture Fair in 2004. She was invited (with designer Hella Jongerius) to create the "Ideal House of the Future" at the Cologne Furniture Fair in 2005. Urquiola's work, which is actually stylish and functional, is carried by such swanky stores as De Padova, Moroso, and B&B Italia.

Photo: Lazy collection by Patricia Urquiola for B&B Italia.

Keller is the founder of Art Basel Miami Beach, a four-day bash that draws contemporary artists, critics, gallerists, and collectors. Last year they got a multimedia fiesta: 195 galleries, plus concerts, a video lounge, floats, sculptures, and performance artists. Ninety American museums, 600 art galleries, and more than 30,000 visitors showed up.

Unraveling the first human genome took 13 years and $3 billion. Within five years, scientists aim to have that down to 90 seconds and $1,000. Church wants folks to offer up DNA for a public database that researchers, physicians, and private companies will use to test hypotheses and study genetic patterns.

Mather takes a more targeted approach than most biotech companies, looking at just 1% or 2% of the proteins in a disease cell--the surface of the cell--as potential targets for the antibodies she develops. Mather has raised $115 million in venture capital and has a colorectal-and-pancreatic-cancer drug in clinical trials.

The world's water supply will continue to dry up in the next decade. General Electric dropped $1.1 billion to buy Ionics, a desalination and water-recycling company, and made it the core of its "Ecomagination" program. In 2005, the water division earned $2 billion, a figure expected to hit $10 billion by 2016.

The tradition for bringing stocks to market is suspicious: bankers price an initial public offering at a discount, then invite their cronies and big customers to buy in. Hambrecht created the "open IPO," where anyone bids for shares in online auctions. His open IPO idea was used in 2004 by Google.

Michael Viscardi won, at 16, the $100,000 Siemens Westinghouse prize for his theorem that models how heat travels across metal surfaces. It could improve space-shuttle and airplane-wing design.

Blue State Digital, a consultancy that helps incorporate Web technology into lefty campaign strategies, was started by Johnson, Rospars, Franklin-Hodge, and Self, veterans of the Internet component of Howard Dean's Oval Office run. Soon, candidates will use GPS and mapping technology to target voters in key states, block by block.

The video-game mastermind behind The Sims franchise now aims to bring out the intelligent designer in all of us. Due in late 2006, Wright's new game, Spore, lets players design life-forms, from the single-celled to intergalactic predators. They evolve as they move through a sci-fi landscape of the gamer's devising.

Amazon, Google, Microsoft and Yahoo are all creating searchable online databases of books. HarperCollins, though, is building its own database. The idea is that search engines will find it easier to link to HarperCollins's database than making their own. A database also frees Friedman to experiment with online sales.

The Strategic National Stockpile was set up in 1999 to plan the medical response to a bioterror attack or pandemic, and maintain a network of 12 secret warehouses filled with the supplies to counteract bioterrorism or an outbreak of disease. The goal is to deliver supplies anywhere in the U.S. within 12 hours.

Robert and his son Bryant spray heated carbon gas over diamond chips; under extreme pressure, the carbon settles on the chips and builds on it. You get diamonds in a week. One-carat stones will be released this year at one-third their usual cost. By 2016, they think half of all diamonds will be lab-grown.

As the Internet becomes the dominant infotainment medium, the portals we use now will try to keep our attention. Semel is already hiring for this: Lloyd Braun from ABC, to create original content; a roving war correspondent, to post video from Iraq; and advertising vet Wenda Harris Millard, to get big brands online.

Getty Images reads the zeitgeist and creates pictures to evoke it--stock images make up 80% of Klein's business. Recently, Getty moved into breaking-news photography, teaming up with Agence France-Presse and a roster of staff photographers. That helped them win a nod from American PHOTO magazine as the number-one "Most Important People in Photography."

Kids at Seattle's Harborview Burn Center have found help in a strange place: SnowWorld, a virtual reality where they glide through icy 3-D canyons, shooting snowballs at penguins. Brain scans show that the game reduces pain by 50%. It's been chosen for the Cooper-Hewitt, National Design Museum's Triennial Show in December.

Brill had his eureka moment after being stopped umpteen times for ID. His solution: the Clear Card. Once you're cleared for the card, you're eligible for private security checkpoints, sidestepping the hell of the modern airport experience. Brill estimates that in five years he'll have 3.5 million customers.

Retired admiral Thomas J. Cassidy took a gamble by building unmanned aerial vehicles on spec. It paid off: Last March, the Air Force committed to buy 156--$5.7 billion worth--of the Cessna-sized Predators. And in August Cassidy won a contract for 132 next-generation drones for the Army.

Located inside your local pharmacy or supermarket, physician assistants or nurses diagnose and prescribe drugs for the most common ailments. They charge between $28 and $110. MinuteClinic runs 90 clinics and is shooting for 300 in 20 states by year's end.

Advanced Metering Infrastructure from ESCO Technologies lets utilities price power hour by hour, based on demand. In November, ESCO landed a $300 million contract for 5 million California buildings. And the federal Energy Policy Act of 2005 encourages all states to evaluate real-time electrical metering.

Ball, a Canadian office-furniture designer and one of the early advocates of cubicles, is the designer behind Herman Miller's biggest launch since 1999. These next-gen cubes are meant to undo the problems that bedevil workers in open-plan systems, creating a sense of territory and privacy while providing the potential for collaboration.

Bock was working at Warner Bros. when he realized if you preach to the largely ignored network of 125 million churchgoers, you'd find success. His Grace Hill Media has pitched more than 80 films to churches and ministries. Bock woos the Christian press to meet with filmmakers, organizes screenings, and creates Bible study guides.

Fast 50 2006 - Part II

A decade ago, this magazine began chronicling a new era in business. To celebrate our anniversary, we're looking out to the next one. In this slideshow (and Part I) meet the people, technology, ideas, and trends that will shape how we work and live over the 10 years ahead.

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